Phillip Koo:

Can you tell us about the bone protective agents? Which are the agents that they should be on?

Zachary Klaassen:

Yeah, there's a few out there. I think, you know, there's, there's, there's Prolia, there is, is, some of these other pills that are out there. There, there's 3 or 4 different ones. I think probably the easiest is whatever your physician's comfortable with, Xgeva is another name for one of them.

And they're given in different doses, they're given in either injections or IV. So, there's no perfect answer for which one you should be on. Just make sure that you're asking your physician, am I… should I be on this? Particularly if you're on that combination we talked about, I think it's an absolute must.

And certainly, when we talk about people being on hormone therapy for, let's say, localized disease, it's not metastatic, you don't need to be on a bone agent in that situation, but what you do need to be on is calcium, Vitamin D supplements.

Making sure you're exercising, keeping your muscle strength, keeping your bones healthy. And so there's a whole discussion around that, but that's sort of a quick one-off in terms of just knowing that this is part of that process, and that all those treatments will deteriorate bones, and certainly will deteriorate skeletal muscle as well.